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1

Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier

Mark Gumbleton, Kenneth L. Audus

Journal:

Journal of Pharmaceutical Sciences

Year:

2001

Language:

english

File:

PDF, 200 KB

english, 2001

2

Coming out of the dark: the evolving role of fluorescence imaging in drug delivery research

Mark Gumbleton, David J. Stephens

Journal:

Advanced Drug Delivery Reviews

Year:

2005

Language:

english

File:

PDF, 133 KB

english, 2005

3

Pharmacokinetic Considerations in Rational Drug Design

Gumbleton, Mark, Sneader, Walter

Journal:

Clinical Pharmacokinetics

Year:

1994

Language:

english

File:

PDF, 739 KB

english, 1994

4

Nanoparticle diffusion within intestinal mucus: Three-dimensional response analysis dissecting the impact of particle surface charge, size and heterogeneity across polyelectrolyte, pegylated and viral particles

Abdulkarim, Muthanna, Agulló, Nuria, Cattoz, Beatrice, Griffiths, Peter, Bernkop-Schnürch, Andreas, Borros, Salvador Gómez, Gumbleton, Mark

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2015

Language:

english

File:

PDF, 875 KB

english, 2015

5

Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain

Schirmer, Lucas, Hoornaert, ChloÃ©, Le Blon, Debbie, Eigel, Dimitri, Neto, Catia, Gumbleton, Mark, Welzel, Petra B., Rosser, Anne E., Werner, Carsten, Ponsaerts, Peter, Newland, Ben

Journal:

Biomaterials Science

Year:

2020

File:

PDF, 3.36 MB

2020

6

Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat

David T.-W. Lau, Mark Gumbleton, Christoph Labisch, Leslie Z. Benet

Journal:

Biopharmaceutics & Drug Disposition

Year:

1991

Language:

english

File:

PDF, 393 KB

english, 1991

7

Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells

Yadollah Omidi, Jaleh Barar, Somaieh Ahmadian, Hamid Reza Heidari, Mark Gumbleton

Journal:

Cell Biochemistry and Function

Year:

2008

Language:

english

File:

PDF, 220 KB

english, 2008

8

Activated extracellular signal-regulated kinase is an independent prognostic factor in clinically confined renal cell carcinoma

Lee Campbell, Rosa Nuttall, David Griffiths, Mark Gumbleton

Journal:

Year:

2009

Language:

english

File:

PDF, 412 KB

english, 2009

9

Caveolin expression during chondrogenesis in the avian limb

Andrew J. Hollins, Lee Campbell, Mark Gumbleton, Darrell J.R. Evans

Journal:

Developmental Dynamics

Year:

2002

Language:

english

File:

PDF, 2.01 MB

english, 2002

10

Nuclear localisation and pDNA condensation in non-viral gene delivery

Elizabeth Collins, James C. Birchall, Julie L. Williams, Mark Gumbleton

Journal:

The Journal of Gene Medicine

Year:

2007

Language:

english

File:

PDF, 246 KB

english, 2007

11

Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono- and dinitrate metabolites

Chao Han, Mark Gumbleton, David T.W. Lau, Leslie Z. Benet

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1992

Language:

english

File:

PDF, 831 KB

english, 1992

12

Gene expression in an intact ex-vivo skin tissue model following percutaneous delivery of cationic liposome–plasmid DNA complexes

James C Birchall, Claire Marichal, Lee Campbell, Ashraf Alwan, Jonathan Hadgraft, Mark Gumbleton

Journal:

International Journal of Pharmaceutics

Year:

2000

Language:

english

File:

PDF, 236 KB

english, 2000

13

Examination of the biophysical interaction between plasmid DNA and the polycations, polylysine and polyornithine, as a basis for their differential gene transfection in-vitro

Euan Ramsay, Jon Hadgraft, James Birchall, Mark Gumbleton

Journal:

International Journal of Pharmaceutics

Year:

2000

Language:

english

File:

PDF, 143 KB

english, 2000

14

Principles in the absorption, distribution and elimination of pharmaceuticals

Mark Gumbleton, Benjamin J. Forbes

Journal:

Pest Management Science

Year:

1994

Language:

english

File:

PDF, 1.79 MB

english, 1994

15

Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C

Sabine Fuchs, Andrew Hollins, Michael Laue, Ulrich Schaefer, Klaus Roemer, Mark Gumbleton, Claus-Michael Lehr

Journal:

Cell and Tissue Research

Year:

2003

Language:

english

File:

PDF, 1.08 MB

english, 2003

16

P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers

Sibylle Endter, Ulrich Becker, Nicole Daum, Hanno Huwer, Claus-Michael Lehr, Mark Gumbleton, Carsten Ehrhardt

Journal:

Cell and Tissue Research

Year:

2007

Language:

english

File:

PDF, 234 KB

english, 2007

17

Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance

Nicholas B. P. Thomas, Iain R. Hutcheson, Lee Campbell, Julia Gee, Kathryn M. Taylor, Robert I. Nicholson, Mark Gumbleton

Journal:

Breast Cancer Research and Treatment

Year:

2010

Language:

english

File:

PDF, 797 KB

english, 2010

18

Expression and Transport Functionality of FcRn within Rat Alveolar Epithelium: A Study in Primary Cell Culture and in the Isolated Perfused Lung

Masahiro Sakagami, Yadollah Omidi, Lee Campbell, Lana E. Kandalaft, Christopher J. Morris, Jaleh Barar, Mark Gumbleton

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 437 KB

english, 2006

19

Identification and biological evaluation of grapefruit oil components as potential novel efflux pump modulators in methicillin-resistant Staphylococcus aureus bacterial strains

Abedel-Nasser Abulrob, Marc T.E. Suller, Mark Gumbleton, Claire Simons, A. Denver Russell

Journal:

Year:

2004

Language:

english

File:

PDF, 385 KB

english, 2004

20

Physical stability and in-vitro gene expression efficiency of nebulised lipid–peptide–DNA complexes

James C Birchall, Ian W Kellaway, Mark Gumbleton

Journal:

International Journal of Pharmaceutics

Year:

2000

Language:

english

File:

PDF, 671 KB

english, 2000

21

Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins

Haefeli, Walter E, Gumbleton, Mark, Benet, Leslie Z, Hoffman, Brian B, Blaschke, Terrence F

Journal:

Clinical Pharmacology & Therapeutics

Year:

1992

Language:

english

File:

PDF, 563 KB

english, 1992

22

Drug Metabolism and Laboratory Anesthetic Protocols in the Rat: Examination of Antipyrine Pharmacokinetics

Mark Gumbleton, Leslie Z. Benet

Journal:

Pharmaceutical Research

Year:

1991

File:

PDF, 614 KB

1991

23

Differential Effects of Anesthetic Regimens on Gentamicin Pharmacokinetics in the Rat: A Comparison with Chronically Catheterized Conscious Animals

Mark Gumbleton, Paul J. Nicholls, Glyn Taylor

Journal:

Pharmaceutical Research

Year:

1990

File:

PDF, 866 KB

1990

24

Percutaneous Penetration Kinetics of Nitroglycerin and Its Dinitrate Metabolites Across Hairless Mouse Skinin Vitro

Toshihiro Kikkoji, Mark Gumbleton, Naruhito Higo, Richard H. Guy, Leslie Z. Benet

Journal:

Pharmaceutical Research

Year:

1991

File:

PDF, 1.20 MB

1991

25

Interpretation and Utilization of Effect and Concentration Data Collected in anin VivoPharmacokinetic andin VitroPharmacodynamic Study

Suneel K. Gupta, Stephen S. Hwang, Leslie Z. Benet, Mark Gumbleton

Journal:

Pharmaceutical Research

Year:

1993

File:

PDF, 976 KB

1993

26

Aberrant Caveolin-1 Expression in Psoriasis: A Signalling Hypothesis

Lee Campbell, Mark Gumbleton

Journal:

Year:

2000

Language:

english

File:

PDF, 345 KB

english, 2000

27

RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models

Sibylle Endter, Danielle Francombe, Dr Carsten Ehrhardt, Mark Gumbleton

Journal:

Journal of Pharmacy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 153 KB

english, 2009

28

Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers

Mark Gumbleton, Leslie Z. Benet

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1993

Language:

english

File:

PDF, 1.03 MB

english, 1993

29

1,2- and 1,3-dinitrate metabolites of nitroglycerin: Spectroscopic characterization and initial administration to man

Mark Gumbleton, John R. Cashman, Leslie Z. Benet

Journal:

International Journal of Pharmaceutics

Year:

1991

Language:

english

File:

PDF, 827 KB

english, 1991

30

Understanding endocytic pathways and intracellular trafficking: a prerequisite for effective design of advanced drug delivery systems

Arwyn T. Jones, Mark Gumbleton, Ruth Duncan

Journal:

Advanced Drug Delivery Reviews

Year:

2003

Language:

english

File:

PDF, 86 KB

english, 2003

31

Challenges and innovations in effective pulmonary systemic and macromolecular drug delivery☆

Mark Gumbleton, Glyn Taylor

Journal:

Advanced Drug Delivery Reviews

Year:

2006

Language:

english

File:

PDF, 76 KB

english, 2006

32

A supplementary review format

Journal:

Advanced Drug Delivery Reviews

Year:

2006

Language:

english

File:

PDF, 74 KB

english, 2006

33

2007 Editors' Collection

Journal:

Advanced Drug Delivery Reviews

Year:

2007

Language:

english

File:

PDF, 84 KB

english, 2007

34

Intersection of nanoscience and modern surface analytical methodology

Journal:

Advanced Drug Delivery Reviews

Year:

2007

Language:

english

File:

PDF, 79 KB

english, 2007

35

2008 Editors' Collection

Journal:

Advanced Drug Delivery Reviews

Year:

2008

Language:

english

File:

PDF, 88 KB

english, 2008

36

Spatial expression and functionality of drug transporters in the intact lung: Objectives for further research

Mark Gumbleton, Ghaith Al-Jayyoussi, Adam Crandon-Lewis, Danielle Francombe, Katharina Kreitmeyr, Chris J. Morris, Mathew W. Smith

Journal:

Advanced Drug Delivery Reviews

Year:

2011

Language:

english

File:

PDF, 222 KB

english, 2011

37

Challenges in inhaled product development and opportunities for open innovation

Ben Forbes, Bahman Asgharian, Lea Ann Dailey, Douglas Ferguson, Per Gerde, Mark Gumbleton, Lena Gustavsson, Colin Hardy, David Hassall, Rhys Jones, Ruth Lock, Janet Maas, Tim McGovern, Gary R. Pitcair

Journal:

Advanced Drug Delivery Reviews

Year:

2011

Language:

english

File:

PDF, 646 KB

english, 2011

38

Molecularly imprinted polymers: macromolecule recognition

Marc Kelly, Jenna Bowen, Mark Gumbleton, Chris Allender

Journal:

Drug Discovery Today

Year:

2010

Language:

english

File:

PDF, 63 KB

english, 2010

39

Phage display identification of a lung transduction peptide that affords enhanced macromolecule transport across the intact lung epithelium

Christopher J. Morris, Peter Griffiths, Neil McKeown, Mark Gumbleton

Journal:

Drug Discovery Today

Year:

2010

Language:

english

File:

PDF, 80 KB

english, 2010

40

In vivo phage display to identify peptides that target the brain

Mathew W. Smith, Mark Gumbleton

Journal:

Drug Discovery Today

Year:

2010

Language:

english

File:

PDF, 66 KB

english, 2010

41

Cellular Delivery of Therapeutic Macromolecules (CDTM) International Symposium 2010: lessons and progress from inter-disciplinary science

Mark Gumbleton, Arwyn T. Jones

Journal:

Drug Discovery Today

Year:

2010

Language:

english

File:

PDF, 109 KB

english, 2010

42

Differential transport of anionic PAMAM dendrimers across in vitro biological barriers

Ghaith Aljayyoussi, Will Ford, Neil McKeown, Mark Gumbleton

Journal:

Drug Discovery Today

Year:

2010

Language:

english

File:

PDF, 67 KB

english, 2010

43

Stereospecific chemical and enzymatic stability of phosphoramidate triester prodrugs of d4T in vitro

Dario Siccardi, Mark Gumbleton, Yadollah Omidi, Chistopher McGuigan

Journal:

European Journal of Pharmaceutical Sciences

Year:

2004

Language:

english

File:

PDF, 100 KB

english, 2004

44

Enhanced pulmonary absorption of a macromolecule through coupling to a sequence-specific phage display-derived peptide

Christopher J. Morris, Mathew W. Smith, Peter C. Griffiths, Neil B. McKeown, Mark Gumbleton

Journal:

Journal of Controlled Release

Year:

2011

Language:

english

File:

PDF, 839 KB

english, 2011

45

A simple zero length surface-modification approach for preparing novel bifunctional supports for co-immobilisation studies

Jenna L. Bowen, Marc A. Kelly, Mark Gumbleton, Philip R. Davies, Chris J. Allender

Journal:

Tetrahedron Letters

Year:

2012

Language:

english

File:

PDF, 626 KB

english, 2012

46

Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood–brain barrier model for drug uptake and transport studies

Yadollah Omidi, Lee Campbell, Jaleh Barar, David Connell, Saeed Akhtar, Mark Gumbleton

Journal:

Year:

2003

Language:

english

File:

PDF, 1.14 MB

english, 2003

47

Targeting caveolae for vesicular drug transport

Mark Gumbleton, Andrew J. Hollins, Yadollah Omidi, Lee Campbell, Glyn Taylor

Journal:

Journal of Controlled Release

Year:

2003

Language:

english

File:

PDF, 307 KB

english, 2003

48

Caveolae as potential macromolecule trafficking compartments within alveolar epithelium

Journal:

Advanced Drug Delivery Reviews

Year:

2001

Language:

english

File:

PDF, 771 KB

english, 2001

49

Caveolae and the caveolins in human disease

Lee Campbell, Mark Gumbleton, Kenneth Ritchie

Journal:

Advanced Drug Delivery Reviews

Year:

2001

Language:

english

File:

PDF, 85 KB

english, 2001

50

Transport of Phosphatidylcholine in MDR3-Negative Epithelial Cell Lines via Drug-Induced MDR1 P-Glycoprotein

Abedel-nasser Ghazi Abulrob, Mark Gumbleton

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 109 KB

english, 1999